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Category: Medhub

Generic Avatrombopag

Avatrombopag is an orally available platelet thrombopoietin receptor (TPOR; MPL) agonist, with potential megakaryopoiesis stimulating activity. Upon administration, avatrombopag binds to and stimulates TPOR, which may lead to the proliferation and differentiation of megakaryocytes from bone marrow progenitor cells. This increases the production of platelets and may prevent chemotherapy-induced thrombocytopenia . . . Read more

Generic Lorlatinib

Lorlatinib is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity. Upon administration, lorlatinib binds to and inhibits both ALK and ROS1 kinases. The kinase inhibition leads to disruption of ALK- and ROS1-mediated signaling and eventually . . . Read more

Generic Selpercatinib

Selpercatinib is an orally bioavailable selective inhibitor of wild-type, mutant and fusion products involving the proto-oncogene receptor tyrosine kinase rearranged during transfection (RET), with potential antineoplastic activity. Upon oral administration, selpercatinib selectively binds to and targets wild-type RET as well as various RET mutants and RET-containing fusion products. This results . . . Read more

Generic Posaconazole

Posaconazole is a potent triazole antifungal agent used in the prevention of invasive fungal infections due to aspergillosis and candida in high risk patients. Posaconazole sold as brand names Noxafil,It has a generic form of several brands include: Square Pharma:Posaconazole Tablet (Delayed Release)- Xpos(Bangladesh) Abbott Pharma:Posaconazole Oral Suspension-Poshope(India) Vital Therapeutics&Formulations:Posaconazole . . . Read more

Generic Nitisinone

Nitisinone is a hydroxyphenyl-pyruvate dioxygenase inhibitor indicated as an adjunct to dietary restriction of tyrosine and phenylalanine in the treatment of hereditary tyrosinemia type 1 (HT-1). Nitisinone sold as brand names Orfadin,It has a generic form of several brands include: Dipharma-Nitisinone(Switzerland) CYCLE pharma:Nityr(US) CYCLE pharma:Pr-Nitisinone(Canada) MendeliKabs:Nitisinone MDK(Canada) OSVAH:Nitisinone-OSVE(Iran) Nobel:Tisinon(Turkey)   . . . Read more

Generic Rucaparib

Rucaparib is an orally bioavailable tricyclic indole and inhibitor of poly(ADP-ribose) polymerases (PARPs) 1 (PARP1), 2 (PARP2) and 3 (PARP3), with potential chemo/radiosensitizing and antineoplastic activities. Upon administration, rucaparib selectively binds to PARP1, 2 and 3 and inhibits PARP-mediated DNA repair. This enhances the accumulation of DNA strand breaks, promotes . . . Read more

Generic Diazoxide

Diazoxide is a benzothiadiazine derivate with antihypertensive and hyperglycemic activities. Diazoxide increases membrane permeability to potassium ions in vascular smooth muscle, thereby stabilizing the membrane action potential and preventing vascular smooth muscle contraction; this results in peripheral vasodilatation and decreases in peripheral vascular resistance. This agent also inhibits insulin release . . . Read more

Generic Nintedanib

Nintedanib is an orally bioavailable, indolinone-derived inhibitor of multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs), with potential antiangiogenic, antifibrotic and antineoplastic activities. Upon administration, nintedanib selectively binds to and inhibits vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR), and . . . Read more

Generic Macitentan

Macitentan is an orally available dual endothelin receptor (ETR) antagonist with potential antihypertensive and antineoplastic activity. Upon administration, macitentan and its metabolites block the binding of endothelin isoform 1 (ET-1) to type-A and type-B ETR on both the tumor cells and the endothelial cells in the tumor vasculature. This prevents . . . Read more

Generic Riociguat

Riociguat is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle. Riociguat is used to treat high blood pressure in the lungs (Pulmonary Hypertension,PH): Chronic thromboembolic pulmonary hypertension(CTEPH) Pulmonary arterial hypertension(PAH) Riociguat sold as brand names Adempas among others.Riociguat has a generic form of several brands include: . . . Read more