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Generic Abemaciclib

Abemaciclib is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. Abemaciclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation in early G1. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of the serine/threonine kinases CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.

Abemaciclib is used to treat:

  • HR-positive and HER2-negative advanced or metastatic breast cancer 

Abemaciclib sold as brand names Verzenio、Ramiven,It has a generic form of several brands include:


 

Ramiven Abemaciclib

Brand Name : Ramiven
Composition : Abemaciclib 50mg&100mg$150mg&200mg
Indication: Antineoplastic-CDK4/6 Inhibitor
Form : Tablet (Oral administration)
Packing : 14 Tablets in 1 box
Manufactured By:Lily [India]
Storage:Store at room temperature (5-30°C)

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