Search Generic Medicine

Medicine Index

Search by generic name

Generic Afatinib

Afatinib is a highly selective tyrosine kinase inhibitor that covalently binds to EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to irreversibly inhibit tyrosine kinase autophosphorylation and downregulate ErbB signaling. Certain EGFR mutations (including nonresistant mutations) result in increased receptor autophosphorylation, leading to receptor activation (sometimes without ligand binding), and may support NSCLC cell proliferation. Nonresistant mutations occur in exons constituting the EGFR kinase domain that lead to increased receptor activation; efficacy is predicted by tumor shrinkage and/or inhibition of cellular proliferation or EGFR tyrosine kinase phosphorylation.

  • The most common mutations are exon 21 L858R substitutions and exon 19 deletions.

Afatinib inhibits autophosphorylation and/or proliferation (in vitro) in cell lines expressing both wild-type EGFR and selected EGFR exon 19 deletion mutations, exon 21 L858R mutations, or other less common nonresistant mutations.

Additionally, afatinib inhibited in vitro proliferation of cell lines overexpressing HER2.

Afatinib is a second generation EGFR tyrosine kinase inhibitor.

Afatinib sold as brand names  GILOTRIF、Xovoltib among others.It has a generic form of several brands include:

  1. Taj Pharma:Guvatib(India)
  2. DRUG INTERNATIONAL Ltd(DIL):Anib 40(Bangladesh)
  3. TUTEUR Pharma:Fanitrix(Argentina)
  4. Caprane Phama(Suspected illegal manufacturer):AFATIB
  5. LUCIUS Phama(Suspected illegal manufacturer):LUCIFA
  6. SP LAB(Suspected illegal manufacturer):AFANIB SPL 40


Afanix Afatinib

Brand Name : Afanix 40
Composition : Afatinib 40mg
Indication: Antineoplastic-2ed generation EGFR TKI
Form : Tablet (Oral administration)
Packing : 30 Tablets in 1 box
Manufactured By:Beacon Pharma [Bangladesh]
Storage:Store at room temperature (5-30°C)

Afanat Afatinib

Brand Name : Afanat
Composition : Afatinib 20mg&30mg&40mg
Indication: Antineoplasic-2ed generation EGFR TKI
Form : Tablet (Oral)
Packing : 30 Tablets in 1 box
Manufactured By:Natco Pharma [India]
Storage:Store at room temperature (5-30°C)

10 Targeted drugs for treatment EGFR lung cancer


You must be logged in to post a comment.