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Generic Bosutinib

Bosutinib is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl and Src kinases with potential antineoplastic activity. Unlike imatinib, bosutinib inhibits the autophosphorylation of both Abl and Src kinases, resulting in inhibition of cell growth and apoptosis. Because of the dual mechanism of action, this agent may have activity in resistant CML disease, other myeloid malignancies and solid tumors. Abl kinase is upregulated in the presence of the abnormal Bcr-abl fusion protein which is commonly associated with chronic myeloid leukemia (CML). Overexpression of specific Src kinases is also associated with the imatinib-resistant CML phenotype.

Bosutinib is used to treat:

  • Accelerated phase Philadelphia chromosome (+) CML
  • Chronic phase Philadelphia chromosome (+) CML
  • Lymphoid blast phase Philadelphia chromosome (+) CML
  • Myeloid blast phase Philadelphia chromosome (+) CML

Bosutinib sold as brand name Bosulif among other.It has a generic form of several brands include:

  1. Sun Pharma:Bonitar(India)
  2. Glenmark:Bosuvi(India)

 

Bosutris Bosutinib

Brand Name : Bosutris
Composition : Bosutinib 100mg&400mg
Indication: Antineoplastic-Protein TKI
Form : Tablet (Oral administration)
Packing : 30 Tablets in 1 box
Manufactured By:Mylan [India]
Storage:Store at room temperature (5-30°C)

Bosutris 500

Brand Name : Bosutris
Composition : Bosutinib 500mg
Indication: Antineoplastic-Protein TKI
Form : Tablet (Oral administration)
Packing : 30 Tablets in 1 box
Manufactured By:Mylan [India]
Storage:Store at room temperature (5-30°C)

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