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Generic Capmatinib

Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation – via mutations, amplification, and/or overexpression – is known to occur in many types of cancer, and leads to overactivation of multiple downstream signaling pathways such as STAT3, PI3K/ATK, and RAS/MAPK. Mutations in MET have been detected in non-small cell lung cancer (NSCLC), and the prevalence of MET amplification in epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)-naive patients with NSCLC has been reported to be 1.4% – 21%. This co-occurrence has made c-Met a desirable target in the treatment of NSCLC.

Capmatinib is used to treat :

  • Mesenchymal-epithelial transition (MET) exon 14 skipping  Non-Small Cell Lung Cancer (NSCLC)

Capmatinib sold as brand names Tabrecta  among others.It has a generic form of several brands include:

  1. SaiLin Pharma(Suspected illegal manufacturer)Tabrecta(Laos)

Capmacare Capmatinib

Brand Name : Capmacare
Composition : Capmatinib 200mg
Indication: Antineoplastic- MET Inhibitor
Form : Tablet (Oral administration)
Packing : 56 Tablets in 1 box
Manufactured By:Elemento Pharma [Laos]

PHOCAPMA Capmatinib

Brand Name : PHOCAPMA
Composition : Capmatinib 200mg
Indication: Antineoplastic- MET Inhibitor
Form : Tablet (Oral administration)
Packing : 56 Tablets in 1 box
Manufactured By: PHARMA 2 VIENTIANE [Laos]

3 MET inhibitors for treatment lung cancer

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