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Generic Dasatinib

Dasatinib Anhydrous is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes.

Dasatinib is used to treat:

  • Accelerated Phase Philadelphia Chromosome (+) CML
  • Chronic Phase Philadelphia Chromosome (+) CML
  • Lymphoid Blast Phase Philadelphia Chromosome (+) CML
  • Myeloid Blast Phase Philadelphia Chromosome (+) CML
  • Philadelphia Chromosome Positive ALL

Dasatinib sold as brand name Sprycel among other.It has a generic form of several brands include:

  1. Incepta Pharma:Dasacent(Bangladesh)
  2. Healthcare Pharma:Danib(Bangladesh)
  3. Genvio Pharma:Mabic(Bangladesh)
  4. MEDIOR Pharma:DASTOR(India) 
  5. DR.REDDY’S:Invista(India) 
  6. CYTOTOXIC:Sprymia(India) 
  7. Cipla Ltd:DASATRUE(India) 
  8. Natco Pharma:DASANAT(India) 
  9. Intas Pharma:DASLEMIA(India) 
  10. SAMARTH Life Sciencese:Dasatib(India) 
  11. Mylan:DasaMyl(India) 
  12. APRAZER Healthcare:Dasakast(India) 
  13. Shilpa Medicare:Dasashil(India) 
  14. ZYDUS Oncosciences:SPNIB(India) 
  15. Arechar HealthCare:DASACINE(India) 
  16. Alkem:Alsatinib(India) 
  17. PlasmaGen:DaPhila(India) 
  18. SP ACCURE LABS:SPRYTRAX(India) 
  19. MSN:TYKODAS(India) 
  20. ADLEY-:BEEDAN(India) 
  21. kimia pharma:Dasatinib(Iran)
  22. Zentiva-Dasatinib(Hungary)
  23. Clonmel Healthcare-Dasatinib(Ireland)
  24. Varifarma:LEUNIB(Argentina)
  25. Pharmaxel(Suspected illegal manufacturer):Dasatinib(Bangladesh)
  26. Caprane(Suspected illegal manufacturer):DASA(India)
  27. LUCIUS(Suspected illegal manufacturer):LUCIDAS(India)
  28. Healeasy Services(Suspected illegal manufacturer):Dasatinib(India)
  29. TheAntiaging(Suspected illegal manufacturer):DasaPro(EU)

Dasanix Dasatinib

Brand Name : Dasanix
Composition : Dasatinib 20mg&50mg&70mg
Indication: Antineoplastic-Protein-TKI
Form : Tablet (Oral administration)
Packing : 30 Tablets in 1 box
Manufactured By:Beacon Pharma[Bangladesh]
Storage:Store at room temperature (5-30°C)

Dyronib Dasatinib

Brand Name : Dyronib
Composition : Dasatinib 20mg&50mg&70mg
Indication: Antineoplastic-Protein-TKI
Form : Tablet (Oral administration)
Packing : 30 Tablets in 1 box
Manufactured By:Hetero Pharma [India]
Storage:Store at room temperature (5-30°C)

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