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Generic Fingolimod

Fingolimod is an orally available derivate of myriocin and sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) modulator, with potential anti-inflammatory and immunomodulating activities. Upon oral administration, fingolimod, as a structural analogue of sphingosine, selectively targets and binds to S1PR1 on lymphocytes and causes transient receptor activation followed by S1PR1 internalization and degradation. This results in the sequestration of lymphocytes in lymph nodes. By preventing egress of lymphocytes. fingolimod reduces both the amount of circulating peripheral lymphocytes and the infiltration of lymphocytes into target tissues. This prevents a lymphocyte-mediated immune response and may reduce inflammation. S1PR1, a G-protein coupled receptor, plays a key role in lymphocyte migration from lymphoid tissues. Fingolimod also shifts macrophages to an anti-inflammatory M2 phenotype, and modulates their proliferation, morphology, and cytokine release via inhibition of the transient receptor potential cation channel, subfamily M, member 7 (TRPM7).

Fingolimod is used to treat:

  • Relapsing form of multiple sclerosis
  • Secondary progressive multiple sclerosis

Fingolimod sold as brand name  Gilenya among other.It has a generic form of several brands include:

  1. HEC Pharm Co. Limited-Fingolimod(China)
  2. Biocon Limited-Fingolimod(India)
  3. Varifarma-Fingolimod-EMULIMOD(Argentina)
  4. Tuteur Pharma-Fingolimod-MOGIBE(Argentina)
  5. Ascendlabs(Alkem Laboratories):Eminod(Chile)
  6. Taro Pharma-Fingolimod(Canada)
  7. Sandoz Canada-Fingolimod(Canada)

 

Fingya Fingolimod

Brand Name : Fingya
Composition : Fingolimod 0.25mg
Indication: Multiple Sclerosis Agent – Sphingosine 1-phosphate receptor modulator
Form : Capsule (Oral administration)
Packing : 28 Capsules in 1 box
Manufactured By:FARMANOVA Pharma [Italy]
Storage:Store at room temperature (5-30°C)

Fingomod Fingolimod

Brand Name : Fingomod
Composition : Fingolimod 0.5mg
Indication: Multiple Sclerosis Agent – Sphingosine 1-phosphate receptor modulator
Form : Capsule (Oral administration)
Packing : 28 Capsules in 1 box
Manufactured By:Sun Pharma [India]
Storage:Store at room temperature (5-30°C)

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