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Generic Ibrutinib

Ibrutinib is an orally bioavailable, small-molecule inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon oral administration, ibrutinib binds to and irreversibly inhibits BTK activity, thereby preventing both B-cell activation and B-cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is required for B cell receptor signaling, plays a key role in B-cell maturation, and is overexpressed in a number of B-cell malignancies. The expression of BTK in tumor cells is also associated with increased proliferation and survival.

Ibrutinib  is  used to treat:

  • Chronic lymphocytic leukemia (CLL)
  • Small lymphocytic lymphoma(SLL)
  • Mantle cell lymphoma(MCL)
  • Marginal zone lymphoma(MZL)
  • Waldenström macroglobulinemia(WM)
  • Graft versus-host disease(GVHD)

Ibrutinib  sold as brand name Imbruvica among other.It has a generic form of several brands include:

  1. Incepta Pharma:Ibrucent(Bangladesh)
  2. Julphar Pharma:Ibrunib(Bangladesh)
  3. DRUG INTERNATIONAL Ltd(DIL):Butinib(Bangladesh)
  4. Genvio  Pharma:Notafol(Bangladesh)
  5. Emcure Pharma:Tybriva(India)
  6. Shilpa Medicare:Ibrushil(India)
  7. Hetero Healthcare:Nitib(India)
  8. Cadila Pharma(ONCOCARE):Ib-Tib(India)
  9. ESPERER Bioresearch:ES-IBRU(India)
  10. Aprazer  Healthcare:Ibrukast(India)
  11. Tuteur Pharma:VILANOR(Argentina)
  12. Varifarma:BINAP(Argentina)
  13. Mongla Weiyang(Suspected illegal manufacturer):IRUTINE(Myanmar)
  14. LUCIUS  Pharma(Suspected illegal manufacturer):Lucibru(India)
  15. SP Labs(Suspected illegal manufacturer):IMBRU(India)

Ibrunat Ibrutinib

Brand Name : Ibrunat
Composition : Ibrutinib 140mg
Indication: Antineoplastic-BTK inhibitors
Form : Capsule (Oral administration)
Packing : 30 Capsules in 1 box
Manufactured By:Natco Pharma [India]
Storage:Store at room temperature (5-30°C)

Emlutini Ibrutinib

Brand Name : Emlutini
Composition : Ibrutinib 140mg
Indication: Antineoplastic-BTK inhibitors
Form : Capsule (Oral administration)
Packing : 90 Capsules in 1 box
Manufactured By:Tlph [Laos]
Storage:Store at room temperature (5-30°C)

Ibrutix Ibrutinib

Brand Name : Ibrutix
Composition : Ibrutinib 140mg
Indication: Antineoplastic-BTK inhibitors
Form : Capsule (Oral administration)
Packing : 120 Capsules in 1 box
Manufactured By:Beacon Pharma [Bangladesh]
Storage:Store at room temperature (5-30°C)

Ibruxen Ibrutinib

Brand Name : Ibruxen
Composition : Ibrutinib 140mg
Indication: Antineoplastic-BTK inhibitors
Form : Capsule (Oral administration)
Packing : 120 Capsules in 1 box
Manufactured By:Everest Pharma [Bangladesh]
Storage:Store at room temperature (5-30°C)

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