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Generic Macitentan

Macitentan is an orally available dual endothelin receptor (ETR) antagonist with potential antihypertensive and antineoplastic activity. Upon administration, macitentan and its metabolites block the binding of endothelin isoform 1 (ET-1) to type-A and type-B ETR on both the tumor cells and the endothelial cells in the tumor vasculature. This prevents ET-1 mediated signaling transduction which may decrease tumor cell proliferation, progression, and angiogenesis in tumor tissue. ET-1, a potent vasoconstrictor that plays an important role in inflammation and tissue repair, is, together with its receptors, overexpressed varyingly in many tumor cell types.

Macitentan is used to treat:

  • Pulmonary arterial hypertension(PAH)

Macitentan sold as brand names Opsumit、ZEPENDO among others.Macitentan has a generic form of several brands include:

  1. Lupin Ltd:Macikad(India) 
  2. MSN Labs:Macitent(India) 
  3. Tuteur Pharma:Mazimit(Argentina) 

Opsutan Macitentan

Brand Name : Opsutan
Composition : Macitentan 10mg
Indication: Pulmonary Arterial Hypertension – Endothelin Receptor Antagonists
Form : Tablet (Oral administration)
Packing : 10 Tablets in 1 box
Manufactured By:Cipla Ltd [India]
Storage:Store at room temperature (5-30°C)

Macietan Macitentan

Brand Name : Macietan
Composition : Macitentan 10mg
Indication: Pulmonary Arterial Hypertension – Endothelin Receptor Antagonists
Form : Tablet (Oral administration)
Packing : 30 Tablets in 1 box
Manufactured By:TLPH [Laos]
Storage:Store at room temperature (5-30°C)

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