Midostaurin is a synthetic indolocarbazole multikinase inhibitor with potential antiangiogenic and antineoplastic activities. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.
Midostaurin is used to treat：
- Acute myeloid leukemia
- Myelodysplastic syndrome
- Advanced systemic mastocytosis.
Midostaurin sold as brand name Rydapt、Tauritmo among other.It has a generic form of several brands include:
Brand Name : TAURITMO
Composition : MIDOSTAURIN 25mg
Indication: Antineoplastic-Protein TKI
Form : Capsule (Oral administration)
Packing : 28 Capsules（ 4 Packs of 28）
Manufactured By：Novartis [India]
Storage:Store at room temperature (5-30°C)