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Generic Nilotinib

Nilotinib is an orally bioavailable aminopyrimidine-derivative Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity. Designed to overcome imatinib resistance, nilotinib binds to and stabilizes the inactive conformation of the kinase domain of the Abl protein of the Bcr-Abl fusion protein, resulting in the inhibition of the Bcr-Abl-mediated proliferation of Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) cells. This agent also inhibits the receptor tyrosine kinases platelet-derived growth factor receptor (PDGF-R) and c-kit, a receptor tyrosine kinase mutated and constitutively activated in most gastrointestinal stromal tumors (GISTs). With a binding mode that is energetically more favorable than that of imatinib, nilotinib has been shown to have an approximately 20-fold increased potency in kinase and proliferation assays compared to imatinib.

Nilotinib is used to treat:

  • Accelerated phase Philadelphia chromosome (+) CML
  • Chronic phase Philadelphia chromosome (+) CML

Nilotinib sold as brand name Tasigna among other.It has a generic form of several brands include:

  1. Renata Limited:Niloren(Bangladesh)
  2. kimia Pharma:Kimonil(Iran)
  3. ACTIZA PHARMA-Nilotinib(India) 
  4. CAPRANE Pharma(Suspected illegal manufacturer):Nilotib(India) 
  5. LUCIUS Pharma(Suspected illegal manufacturer):LUCINIL(India) 

 

Nilonix 150

Brand Name : Nilonix 150
Composition : Nilotinib 150mg
Indication: Antineoplastic-Protein TKI
Form : Capsule (Oral administration)
Packing : 120 Capsules in 1 box
Manufactured By:Beacon Pharma[Bangladesh]
Storage:Store at room temperature (5-30°C)

Nilonix 200

Brand Name : Nilonix 200
Composition : Nilotinib 200mg
Indication: Antineoplastic-Protein TKI
Form : Capsule (Oral administration)
Packing : 120 Capsules in 1 box
Manufactured By:Beacon Pharma[Bangladesh]
Storage:Store at room temperature (5-30°C)

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