RxLibra

Search Generic Medicine

Medicine Index

Search by generic name

Generic Nintedanib

Nintedanib is an orally bioavailable, indolinone-derived inhibitor of multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs), with potential antiangiogenic, antifibrotic and antineoplastic activities. Upon administration, nintedanib selectively binds to and inhibits vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR), and colony stimulating factor 1 receptor (CSF1R) tyrosine kinases, which may result in the induction of endothelial cell apoptosis, the reduction in tumor vasculature, the inhibition of tumor cell proliferation and migration, and antifibrotic activity in pulmonary fibrosis. In addition, nintedanib also binds to and inhibits members of the Src family of tyrosine kinases, including Src, Lck and Lyn, and fms-like tyrosine kinase 3 (FLT-3). VEGFR, FGFR, PDGFR and CSF1R RTKs play key roles in tumor angiogenesis, tumor cell proliferation and metastasis, as well as pulmonary fibrosis.

Nintedanib is used to treat:

  • Idiopathic pulmonary fibrosis
  • Progressive fibrosing interstitial lung disease
  • Systemic sclerosis-associated interstitial lung disease

Nintedanib sold as brand names Ofev、Vargatef、Cyendiv among others.Nintedanib has a generic form of several brands include:

  1. Beacon Pharma:Nindanix、Fibroz(Bangladesh)
  2. Unimed Unihealth:Nifev(Bangladesh)
  3. Sun Pharma:Nintena(India) 
  4. Cipla Ltd:Nintib(India) 
  5. ADLEY:NINTAD(India) 
  6. BDR Pharma:NINTENIB(India) 
  7. Lupin Ltd:Idofnib(India) 

 

Nindanib Nintedanib

Brand Name : Nindanib
Composition : Nintedanib 100mg&150mg
Indication: Antineoplastic-Protein-TKI·Pulmonary Fibrosis Treatment Agents-Multikinase Inhibitors
Form : Capsule (Oral administration)
Packing : 30 Capsules in 1 box
Manufactured By:Glenmark [India]
Storage:Store at room temperature (5-30°C)

Nydeni Nintedanib

Brand Name : Nydeni
Composition : Nintedanib 100mg&150mg
Indication: Antineoplastic-Protein-TKI·Pulmonary Fibrosis Treatment Agents-Multikinase Inhibitors
Form : Capsule (Oral administration)
Packing : 30 Capsules in 1 box
Manufactured By:TLPH [Laos]
Storage:Store at room temperature (5-30°C)

Tags:  

You must be logged in to post a comment.