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Generic Ponatinib

Ponatinib is an orally bioavailable multitargeted receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities. Ponatinib inhibits unmutated and all mutated forms of Bcr-Abl, including T315I, the highly drug therapy-resistant missense mutation of Bcr-Abl. This agent also inhibits other tyrosine kinases including those associated with vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs); in addition, it inhibits the tyrosine kinase receptor TIE2 and FMS-related tyrosine kinase receptor-3 (Flt3). RTK inhibition by ponatinib may result in the inhibition of cellular proliferation and angiogenesis and may induce cell death. Bcr-Abl is a fusion tyrosine kinase encoded by the Philadelphia chromosome.

Ponatinib is used to treat:

  • Blastic Phase Chronic Myeloid Leukemia (CML)
  • Chronic Phase Chronic Myeloid Leukemia (CML)
  • Philadelphia Chromosome Positive ALL (ALL)
  • Accelerated phase chronic Myelocytic Leukemia(CML)

Ponatinib sold as brand name CLusig .It has a generic form of several brands include:

  1. Varifarma:PONATIB(Argentina)
  2. LUCIUS(Suspected illegal manufacturer):LUCIPONA(India)
  3. Pharmaxel(Suspected illegal manufacturer):Ponanib(Bangladesh)

Ponatinix 15

Brand Name : Ponatinix
Composition : Ponatinib 15mg
Indication: Antineoplastic-Multikinase Inhibitors
Form : Tablet (Oral administration)
Packing : 60 Tablets in 1 box
Manufactured By:Beacon Pharma [Bangladesh]
Storage:Store at room temperature (5-30°C)

Ponatinix 45

Brand Name : Ponatinix
Composition : Ponatinib 45mg
Indication: Antineoplastic-Multikinase Inhibitors
Form : Tablet (Oral administration)
Packing : 30 Tablets in 1 box
Manufactured By:Beacon Pharma [Bangladesh]
Storage:Store at room temperature (5-30°C)

Ponaxen 15

Brand Name : Ponatinix
Composition : Ponatinib 15mg
Indication: Antineoplastic-Multikinase Inhibitors
Form : Tablet (Oral administration)
Packing : 30 Tablets in 1 box
Manufactured By:Everest Pharma [Bangladesh]
Storage:Store at room temperature (5-30°C)

Ponaxen 45

Brand Name : Ponatinix
Composition : Ponatinib 45mg
Indication: Antineoplastic-Multikinase Inhibitors
Form : Tablet (Oral administration)
Packing : 30 Tablets in 1 box
Manufactured By:Everest Pharma [Bangladesh]
Storage:Store at room temperature (5-30°C)

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