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Generic Rucaparib

Rucaparib is an orally bioavailable tricyclic indole and inhibitor of poly(ADP-ribose) polymerases (PARPs) 1 (PARP1), 2 (PARP2) and 3 (PARP3), with potential chemo/radiosensitizing and antineoplastic activities. Upon administration, rucaparib selectively binds to PARP1, 2 and 3 and inhibits PARP-mediated DNA repair. This enhances the accumulation of DNA strand breaks, promotes genomic instability and induces cell cycle arrest and apoptosis. This may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARPs are enzymes activated by single-strand DNA breaks that catalyze the post-translational ADP-ribosylation of nuclear proteins, which induces signaling and the recruitment of other proteins to repair damaged DNA. The PARP-mediated repair pathway plays a key role in DNA repair and is dysregulated in a variety of cancer cell types.

Rucaparib is used to treat:

  • Ovarian Cancer
  • Fallopian tube Cancer
  • Peritoneal Cancer
  • Prostate Cancer

Rucaparib sold as brand names Rubraca,It has a generic form of several brands include:

  1. BDR  Pharma:BDPARIB(India)
  2. Zydus:NUPARP (India)
BDPARIB Rucaparib

Brand Name : BDPARIB
Composition : Rucaparib 200mg&300mg
Indication: Antineoplastic – Poly (ADP-ribose) polymerase (PARP) inhibitors
Form : Tablet (Oral administration)
Packing :60 Tablets in 1 box
Manufactured By:BDR  Pharma [India]
Storage:Store at room temperature (5-30°C)

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