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Generic Selpercatinib

Selpercatinib is an orally bioavailable selective inhibitor of wild-type, mutant and fusion products involving the proto-oncogene receptor tyrosine kinase rearranged during transfection (RET), with potential antineoplastic activity. Upon oral administration, selpercatinib selectively binds to and targets wild-type RET as well as various RET mutants and RET-containing fusion products. This results in an inhibition of cell growth of tumors cells that exhibit increased RET activity. In addition, selpercatinib targets, binds to and inhibits vascular endothelial growth factor receptor 1 (VEGFR1) and 3 (VEGFR3), and fibroblast growth factor receptor 1 (FGFR1), 2 (FGFR2), and 3 (FGFR3). RET overexpression, activating mutations, and fusions result in the upregulation and/or overactivation of RET tyrosine kinase activity in various cancer cell types; dysregulation of RET activity plays a key role in the development and progression of these cancers.

Selpercatinib is used to treat certain types of cancer ,such as:

  • Lung cancer
  • Thyroid cancer
  • Medullary thyroid cancer – MTC

Selpercatinib sold as brand names Retevmo,It has a generic form of several brands include:

  1. Mongla Weiyang Pharma(Suspected illegal manufacturer):SELPERCATINI(Myanmar)

PHOSELP Selpercatinib

Brand Name : PHOSELP
Composition : Selpercatinib 40mg
Indication: Antineoplastic-BTK inhibitors
Form : Capsule (Oral administration)
Packing : 60 Capsules in 1 box
Manufactured By:PHARMA 2 VIENTIANE [LAO]
Storage:Store at room temperature (5-30°C)

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