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Tag: Lymphoma

Generic Acalabrutinib

Acalabrutinib is an orally available inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, acalabrutinib inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to . . . Read more

Generic Plerixafor

Plerixafor injection is in a class of medications called hematopoeitic stem cell mobilizers. It works by causing certain blood cells to move from the bone marrow to the blood so that they can be removed for transplant.  Plerixafor is used by patients with certain types of cancer (non-Hodgkin’s lymphoma-NHL, multiple myeloma-MM) . . . Read more

Generic Lenalidomide

Lenalidomide is a thalidomide analog with potential antineoplastic activity. Lenalidomide inhibits TNF-alpha production, stimulates T cells, reduces serum levels of the cytokines vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), and inhibits angiogenesis. This agent also promotes G1 cell cycle arrest and apoptosis of malignant cells. Lenalidomide  . . . Read more

Generic Ibrutinib

Ibrutinib is an orally bioavailable, small-molecule inhibitor of Bruton’s tyrosine kinase (BTK) with potential antineoplastic activity. Upon oral administration, ibrutinib binds to and irreversibly inhibits BTK activity, thereby preventing both B-cell activation and B-cell-mediated signaling. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. . . . Read more

Generic Crizotinib

Crizotinib is an inhibitor that makes minimal interactions with the ATP-binding pocket, and thus inhibits many kinases, including ALK、ROS1 and c-MET.  Crizotinib is used to treat : ALK Positive Non-Small Cell Lung Cancer (NSCLC) ROS1 Positive non-small cell lung cancer (NSCLC) ALK Positive Anaplastic large-cell lymphoma (ALCL) Crizotinib sold as . . . Read more