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Tag: Ovarian Cancer

Generic Rucaparib

Rucaparib is an orally bioavailable tricyclic indole and inhibitor of poly(ADP-ribose) polymerases (PARPs) 1 (PARP1), 2 (PARP2) and 3 (PARP3), with potential chemo/radiosensitizing and antineoplastic activities. Upon administration, rucaparib selectively binds to PARP1, 2 and 3 and inhibits PARP-mediated DNA repair. This enhances the accumulation of DNA strand breaks, promotes . . . Read more

Generic Niraparib

Niraparib is a once-daily, oral medicine used for the maintenance treatment of women with newly diagnosed advanced ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. Niraparib is the first and only once-daily PARP inhibitor. It is used after the cancer has responded (complete or partial response) to treatment with . . . Read more

Generic Olaparib

Olaparib is a small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib is approved to treat: Breast cancer that is HER2 negative, has certain germline mutations in the BRCA1 or BRCA2 gene, and has metastasized (spread to other parts of the . . . Read more