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Tag: Pulmonary Hypertension

Generic Macitentan

Macitentan is an orally available dual endothelin receptor (ETR) antagonist with potential antihypertensive and antineoplastic activity. Upon administration, macitentan and its metabolites block the binding of endothelin isoform 1 (ET-1) to type-A and type-B ETR on both the tumor cells and the endothelial cells in the tumor vasculature. This prevents . . . Read more

Generic Riociguat

Riociguat is a stimulator of guanylate cyclase which causes relaxation of vascular smooth muscle. Riociguat is used to treat high blood pressure in the lungs (Pulmonary Hypertension,PH): Chronic thromboembolic pulmonary hypertension(CTEPH) Pulmonary arterial hypertension(PAH) Riociguat sold as brand names Adempas among others.Riociguat has a generic form of several brands include: . . . Read more